Don Conrad, PhD is a world-renowned expert in genetics/genomics and the development of bioinformatics pipelines/platforms for the efficient assessment and management of genetic data. He played a leading role in mapping and characterizing the functional impact of human chromosomal structural variants. He also developed novel statistical methods for identifying de novo point mutations from next-generation sequencing data and used this to estimate germline mutation rates from parent-offspring trios as part of the 1000 genomes project.
A major emphasis of his current research includes defining the origins of mutation and the distribution of mutation frequencies that impact gametogenesis, fertilization, and pregnancy. He is founder of the Genetics of Male Infertility Initiative (GEMINI) which is an international network of andrology investigators.
Don received his training at the University of Chicago and the Wellcome Trust Sanger Institute prior to joining Washington University in St. Louis, where he led a successful research group in the Department of Human Genetics. He joined the ONPRC in 2018 to lead the newly established Division of Genetics.
Current Lab Members
Jasvinder Ahuja joined Conrad lab as a Research Assistant Professor in 2022. His research is focused on investigating segregation of homologous chromosomes during meiosis/ gametogenesis, a process that involves repair of self-inflicted chromosomal breaks. Each one of us has inherited exactly one chromosome of each type from each parent, who have two copies of each chromosome of their own. Most discrepancies in chromosome number among gametes lead to premature spontaneous abortions, few individuals with abnormal number of autosomal chromosomes may survive but would not make it to adulthood. Furthermore, none of the inherited autosomal chromosomes in a gamete is identical to any chromosome in the respective parental genome. In fact, each of the autosomal chromosomes inherited in a gamete is a unique recombined version containing parts from both grandparents. The process of recombination involves formation and accurate repair of ~150 chromosomal breaks per cell undergoing gametogenesis. Imagine millions of sperm per ejaculate!
Therefore, errors in repair of chromosomal breaks lead to infertility and have Jasvinder’s special attention. Notably, these very processes are disrupted in many cancer syndromes, causing genome rearrangements. Furthermore, targeting mechanisms required for maintenance of genome integrity negatively impacts cell proliferation and has provided the basis for many cancer chemotherapies.
Jasvinder did his Ph.D. in Regulatory Biology with a primary focus on chromosome segregation during meiosis in a joint program offered by Cleveland State University and the Cleveland Clinic in 2014. During his Ph.D. he discovered that the proteasome is recruited to meiotic chromosomes, where it facilitates homolog pairing and recombination (Science, 2017). His postdoctoral research at National Cancer Institute (Bethesda) has provided insights into the molecular mechanisms of meiotic recombination in greater detail than ever before and led to the disassembly/migration-annealing model for meiotic recombination (Mol. Cell., 2021).
Outside of work, Jasvinder enjoys long walks, reading and photography.
Arvand joined the Conrad Lab in January 2023 as a postdoc. His research is focused on unravelling the genetics of the most severe forms of infertility through the use of high-throughput sequencing combined with cellular and mechanistic functional verifications based on the nature of the genetic mutation in question.
Arvand did his PhD at Azad University – Science and Research in Tehran, Iran. His thesis, which was a collaboration between his university, Royan Institute and Università Vita-Salute San Raffaele was titled “A whole-exome sequencing study of non-syndromic asthenozoospermia in infertile males of three consanguineous families”.
After his PhD, Arvand was a postdoc at Royan Institute during which he worked on the genomics of male and female infertility.
Outside of the lab, Arvand enjoys reading, walking, biking, discovering new places and exploring the beautiful nature of Portland area.
Fritzie joined the Conrad lab as a Senior Research Associate in July 2022. Her research background utilizes fish models to study the roles of hormones and the effects of environmental stressors including endocrine disrupting chemicals on growth, reproduction, and stress response.
Fritzie is excited to venture into biomedical research, and she is currently contributing to the technical aspects of several projects in the Conrad lab as well as in the management of the wet lab. She is looking forward to characterize the normal function of the testis, as well as the effects of environmental and genetic causes of testicular dysfunction in mammals. She is also interested in the roles of stress and immune responses in pathology.
Fritzie completed her PhD in Bioresource Production Science (Aquaculture and Livestock Production- Fish Reproductive Physiology) in the laboratory of Prof. Takeshi Miura at Ehime University in Matsuyama, Japan. Her dissertation focused mainly on endocrine physiology, in which she studied the effects of arsenic and oxidative stress on spermatogenesis and the mechanism of their effects involving the antioxidant defense system in the testis using the Japanese eel (Anguilla japonica) as a model. The results of this research work provided insights into the molecular mechanisms of the tolerance of spermatogonia to oxidative stress.
She worked as a Research Specialist at the University of Hawaii in Honolulu where she led a research project in determining the long-term effects of early-life exposure to estrogenic endocrine disrupting chemicals on growth and reproductive physiology in tilapia. One of her major works also include characterizing the mechanisms associated with the endocrine control of growth and reproduction that may underlie sexual dimorphism using tilapia as a model.
Outside the lab, Fritzie loves photography, road trips, discovering new places, and fishing.
Jenna joined the Conrad Lab in May 2022 as a Research Assistant. She is working on the newly funded dGTEx project.
She received her B.S. in Biology from Pacific University where her thesis work was about dispersal methods and biodiversity of ciliates in the Pacific Northwest with Dr. Jon Schnorr. She previously worked as a lab technician in a microbiology lab where they tested food products for harmful microorganisms in accordance to the FDA.
Outside of the lab, Jenna is an avid plant hobbyist and loves to garden and do anything crafty.
Madison joined the Conrad Lab as an intern in March 2021. Since then, she has worked on projects such as GEMINI and SATINN, helping with data processing and image analysis.
She received her B.A. in Biology from Reed College in 2023 after completing her undergraduate thesis. Under the guidance of both Dr. Conrad and Dr. Sarah Schaack, Reed College, Madison wrote her thesis on the effects of the epigenetic modifier protein PRDM9 on repeat genomic regions. She is excited to continue growing her knowledge and furthering her love for scientific research as a Research Assistant
Outside of the lab, she loves to cook, bake, and play with her (or other people’s) dogs.
Tien joined the Conrad Lab in December 2019 as the Administrative Coordinator for the Division of Genetics. She performs all aspects of admin support, including grant submissions, purchasing, scheduling and HR.
Tien received her BA in International Studies from Portland State University with a minor is Business Administration. She spend a year at Soocchunhyang University in South Korea as an exchange student. Before joining OHSU, Tien was the assistant manager at Can Tho Market where she was in charge of inventories, bookkeeping and day-to-day administration.
Outside of work, Tien enjoys watching Korean dramas on Netflix and hiking with friends when the weather is nice!
Phil joined the Conrad Lab as the Project Manager for the Marmoset Coordinating Center (MCC) in July 2022. She is also Project Manager for ONPRC’s ART Core (Assisted Reproductive Technology) and OPERM (Oregon Permanent Contraception Research Center).
Phil received her BA in Biology from Carleton College and her PhD in Neuroscience from Georgetown University (Dr. Jean Wrathall) where her research focused on plasticity in the spinal cord as related to urinary tract function after spinal cord injury. She then joined OHSU as a postdoctoral fellow working on stroke and neuroprotection (Dr. Mary Stenzel-Poore) before working as a scientist and project manager for an IND-stage biotherapeutics company in the Bay Area.
Outside of work, Phil enjoys eating and cooking, traveling, playing tennis, and spending time with her human and canine family members.
Ana joined the Conrad lab as a post-doctoral fellow in August 2016.
One can say that Ana has always enjoyed a complex puzzle. Her passion for problem solving and learning has led her to explore the field of Genetics in many contexts.
She received her PhD at the University of Porto in 2016 and was co-advised by Don, thus spending time the Conrad Lab since 2012. During her doctoral work, Ana came across one of the major challenges of Human genetics: How to interpret the functional relevance of genetic variation in the context of disease? She has since been fascinated by the complexity of the mechanisms regulating expression of genes into a variety of functional proteins. Currently, Ana is interested in understanding the regulatory networks that control spermatogenesis progression, mainly focusing on post-transcriptional regulation, and how the disruption of these fine-tuned mechanisms may affect germ cell development and lead to male infertility. Her most recent challenge has been to put her pipettes down and integrate computational approaches in her research.
Outside of science, Ana has been dancing since she was 4 years old, having taught ballet to children and experience in more than a handful of styles. She also loves crafting and is crazy about her dog!
Helen joined the Conrad lab as a computational biologist in September 2021. Although her background is in geobiology, she is excited to apply the bioinformatic skills she learned from her research experiences to human and non-human primate genetic data and is contributing to several projects in the Conrad lab.
Helen received her Bachelor's degree in Biology at Willamette University in 2020 where she did geomicrobiology research looking for novel Asgard Archaea in Oregon Coast sediment samples utilizing genomics and microscopy techniques. She then received her Master of Natural Science (Geological Sciences) at Arizona State University in August 2021 where her project focused on carbon utilization of deep sea marine microbes in hydrothermal vent systems. In this project, she utilized bioinformatic techniques to craft a data pipeline to analyze metagenomic and metatranscriptomic data to find inorganic carbon associated genes transcribed by microbes in these deep sea hydrothermal vents.
Helen also worked in the Genomics Unit at Rocky Mountain Laboratories, part of the NIH Intramural Research Program, in Hamilton, MT in 2015-2016.
Outside of the lab, Helen enjoys hiking with her dog, going to the coast, cooking, and reading.
Eisa joined the Conrad lab as a computational biologist in December 2018 and is focused on solving problems at the scope of single-cells. He was promoted do Research Assistant Professor in 2022.
In the Conrad Lab his main role is to develop robust computational methods to integrate and processes biomedical data as well as addressing specific clinical hypotheses that require bioinformatics. More specifically, he aims to understand male-infertility by interrogating the cells of the testis. Long-term, Eisa is interested in the role of the immune system in various pathology; from infectious diseases and oncology to common and idiopathic conditions.
He received his PhD from OHSU in bioinformatics and computational biology. His dissertation focused on developing a machine learning framework to classify rare cellular subsets in single-cell transcriptomic data.
Outside of work, Eisa enjoys mostly the warmer seasons, being outdoors, eventually sitting under a tree by a river or lake, sipping on a cup of tea and reading something interesting.
For more details, visit: https://eisascience.github.io
Malachi joined the Conrad Lab in October 2021 as a clinical research assistant. He is based in the Department of Urology and he coordinates patient recruitment for the GEMINI study at OHSU.
Malachi received his B.S. in Cellular, Molecular, and Developmental Biology from Colorado Mesa University. His senior thesis focused on the outcomes of various stem cell therapies on multiple sclerosis patients. He previously volunteered with the Urology department during the summers of his undergraduate education on various projects, and he is also currently working with Pediatric Urology on creating a national registry for patients with disorders of sexual development.
Outside of work, Malachi enjoys finding new places to eat in Portland, hiking, and playing soccer. He also recently picked up golf and chess as new hobbies when the pandemic started.
Caitlin joined the Conrad Lab in April 2022 as a graduate student.
In the Conrad lab, she'll be working on computational biology, mostly on the GEMINI project with the Phase I and II "hit" gene variant lists. She is currently learning to code!
Caitlin received her bachelor's degree in human biology at the University of Montana in Missoula, MT. She then spent four years at the University of California, San Francisco studying genetic predisposition to non-alcoholic fatty liver disease in a stem cell model. She received her master's degree in cell and molecular biology, emphasizing stem cell biology at San Francisco State University. Her thesis work involved CRISPR/Cas9 screening of genes perturbing lipid metabolism homeostasis in a stem-cell-derived liver model.
Outside of the lab, Caitlin loves to hang out with her partner and her kitty. She likes to watch YouTube cooking videos and have dinner parties, do DIY projects, thrift for fun clothes, swim, and binge-read novels.
Antoni joined the Conrad Lab as a postdoctoral researcher in May 2023. His research interests primarily focus on deciphering the genetic causes of male infertility and their potential role in comorbidities. In the Conrad Lab, he will be working within the GEMINI project.
Antoni received his PhD from the University of Florence in 2017 and went on to pursue a postdoctoral fellowship at Fundació Puigvert in Barcelona. During his PhD and postdoctoral work, he focused on the discovery of novel genetic causes of non-obstructive azoospermia and testicular cancer by utilizing high-throughput approaches, including array-CGH and exome sequencing.
When he's not in the lab, Antoni enjoys exploring new places, discovering local restaurants, cooking, hiking, visiting wineries, and spending quality time with his loved ones.
Tora is a Research Associate Professor in the Division of Reproductive & Developmental Sciences at ONPRC and is a close collaborator of the Conrad Lab. She is a placenta nerd! The placenta is a remarkable organ that supports the growth and development of the fetus while also growing itself. Regulation of function needs to be tightly controlled to ensure a healthy outcome for both mother and baby. During her studies and early career, Tora worked with human samples and since the start of 2009, she has been at the ONPRC utilizing pregnant nonhuman primate (NHP) models. She is a rare find in science, a researcher who has never used a rodent model!
Tora got involved in with the Conrad Lab in April 2022 as the Program Manager for the NHP dGTEx (developmental genotype tissue expression) consortium. Her experience with pregnant NHPs is an excellent fit in running this project which will build a large unique tissue and genomic data resource from both old and new world monkey species. Tora is especially excited about obtaining early gestation placenta samples which she will utilize to develop a 3-dimensional trophoblast organoid model system from the rhesus macaque.
Tora obtained her PhD in placental physiology from the University of Manchester, UK in 2004. Her research focused on the role of purinergic receptors in placental homeostasis and she gained a lot of experience in using primary cells as an in vitro model system. After obtaining her PhD, she moved to the University of Cincinnati, OH where she completed a 4-year postdoc from 2004 - 2008. During that time, she continued to investigate regulation of placental function, and expanded her interests to mechanistic studies of what goes wrong in compromised pregnancies.
Outside of the lab, Tora loves to bake! She also enjoys reading and swimming but much of her free time involves soccer – mostly cheering from the sidelines! When she eventually retires her lab coat, she’d like to run a dog rescue.
Katinka joined the Conrad Lab as the lab manager in October 2018.
In addition to her lab administrative duties, she is responsible for scientific communications and graphic design.
Katinka received her PhD from the University of Chicago in human genetics, working in the laboratory of Dr. Daphne Preuss. For her thesis she developed an allergen microarray for high dimensional phenotyping and used these data to study the genetic basis of pollen allergy. Katinka has worked in both industry (Abcam) and academia (WUSM) in marketing and communications positions.
Outside of work, Katinka enjoys exploring the beautiful outdoors of Oregon and DIY-ing.
Ran joined the Conrad Lab as a computational biologist in November 2019 and is interested in developing analytical methods on a genomic scale to predict and study molecular mechanisms of genetic factors associated with reproductive defects and other diseases.
Ran received his PhD in Biology from Northwestern University. His dissertation focused on developing image processing and statistical methods to study cell and molecular patterning in fly embryos, and constructing regulatory gene networks.
Outside of work, Ran enjoys longboarding, playing Frisbee, and going to the beach.
Lab Photos
Past Lab Members
- Everyone
- Computational Biologist
- Graduate Student
- Intern
- Post-Doctoral Fellow
- Research Assistant
- Research Faculty
- Rotation Student
- Staff Scientist/Technician
- Undergraduate Research Scholar
- Maris Laan, PhDVisiting Professor (November 2022 - October 2023)University of Tartu, EstoniaMaris Laan, PhDVisiting Professor (November 2022 - October 2023)
- Marie-Sophie OgloblinskyVisiting Scholar (August 2023 - October 2023)University of Brest, FranceMarie-Sophie OgloblinskyVisiting Scholar (August 2023 - October 2023)
Marie-Sophie is visiting the Conrad Lab for three months from the University of Brest - Brittany. She is doing a PhD in biostatistics at the INSERM UMR 1078 Genetics Functional Genomics and Biotechnologies lab, under the supervision of Emmanuelle Génin and Gaëlle Marenne.
Her PhD is focused on the development of new statistical methods to help with the diagnosis of rare heterogeneous diseases. Currently, only 50% of patients affected with a rare genetic disease receive a molecular diagnosis, which highlights the need to improve the current methods to analyze and prioritize variants from sequencing data. To tackle this research question, she became interested in the PSAP method, a variant priorization method for coding variants initially developed in the ConradLab. Marie-Sophie has been working on Easy-PSAP, a new implementation and extension to the whole genome of the PSAP method. During her visit, she will mainly be applying Easy-PSAP to WGS data from families affected by male infertility and look for both coding and non-coding variants involved in the disease. She hopes to learn more about the computational methods developed in the ConradLab and improve her knowledge about the physio-pathology and different causes of infertility. She will also be working on an adaptation of Easy-PSAP to detect digenic inheritance.Marie-Sophie is part of Ecole de l'Inserm, a French national MD-PhD program. She has already completed the first three years of French medical school, followed by a Master's degree at Paris-Saclay University in Health Data Science. During this time, she did two internships. One at INSERM UMR 1078 GGB where she studied the impact of pulmonary microbiome and host genetic on Pseudomonas aeruginosa colonisation in cystic fibrosis patients. The other, she did at INSERM U1141 NeuroDiderot, GenMedStroke Lab where she focused on the identification of rare recessive variants involved in complex traits in consanguineous individuals from UK Biobank data.Outside of the lab she enjoys going running and being active in general, reading any kind of book and taking care of her cat and plants. While in Portland, she has loved exploring the city and its very beautiful surroundings. - Priscila Darakjian, MSComputational Biologist (2022 - 2023)
Priscila joined the Conrad Lab as a computational biologist in April 2022. She has experience in bioinformatics, developing analytical pipelines to mine and integrate genetic data generated from a variety of high throughput technologies.
She has masters degree in Behavioral Ecology and in Bioengineering from the University of Sao Paulo and Oregon State University respectively
In 2004 she started working in the field of bioinformatics at OHSU. Most of her work has been related to the genetics of substance addiction in animal models at the Portland Alcohol Research Center (PARC – OHSU – Department of Behavioral Neuroscience).
She joined the Oregon National Primate Research Center in 2019, collaborating in projects on the epigenetics of alcohol addiction, and neuroendocrine mechanisms related to females after menopause.
- Muhammad Riaz KhanVisiting Scholar (March 2023 - September 2023)University of MalakandMuhammad Riaz KhanVisiting Scholar (March 2023 - September 2023)
Muhammad Riaz joined the Conrad Lab in March 2023 as a visiting scholar from the University of Malakand in Pakistan where he is doing a PhD in Biotechnology with a research focus on the genetics of male infertility. He comes to OHSU through the International Research Support Initiative Program (IRSIP) Higher Education Commission of Pakistan (HEC).
In the Conrad Lab Muhammad Riaz will be working on the GEMINI project, specifically learning about whole genome sequencing, using bioinformatics tools and data analysis. He also hopes to gain experience in manuscript writing. He will be visiting the Conrad Lab for six months.
Muhammad Riaz received his BS and M.Phil in Biotechnology from the University of Malakand, Pakistan.
Outside the lab Muhammad Riaz enjoys learning about new science, reading and exploring new places in Portland.
- Clement Daube, MSVisiting Scholar (March 2023 - August 2023)Clement Daube, MSVisiting Scholar (March 2023 - August 2023)
Clement joined the Conrad Lab in March 2023 as a visiting scholar from the University of Rouen - Normandy where he is a masters student in Bioinformatics and Statistical Modeling. He is part of a special program for students who already have a degree in biology called Complementary Skills in Bioinformatics for Biology and Biomedical Sciences.
In the Conrad Lab he will be working on building a machine learning model to learn expression signatures of special testis cell types from scRNA-seq data. He hopes to gain experience in computational biology and statistics mainly using R language. He will be in the lab for six months.
Clement obtained is bachelors degree from Sorbonne University in Paris in life sciences. He then received a masters degree in molecular and cellular biology, also from Sorbonne University. During his first year, Clement had the opportunity to do an internship in the Sattlegger Lab at Massey University in Auckland, NZ. There he worked with yeast DNA to decipher the function of a particular amino acid in a protein interaction. He then did another internship at I-Stem under the direction of Christian Pinset where he worked on elucidating the function of embryonic dystrophin as part of Duchenne Muscular Disease (DMD).
After his masters degree, Clement worked at the Brain Institute (ICM) in Paris, first working on using CRISPR-Cas9 to modify genes, and then working with Philippe Ravassard and Benjamin Galet to develop an Alzheimer's disease brain organoid model from patients ipsc to study differential gene expression and lncRNA within the disease.
Outside of the lab, Clement loves to cook (and eat), go on hikes, play video games, boulder and play tennis or practice pretty much any sport. He loves spending time with his girlfriend who lives in Portland.
- Daniel LewinsohnIntern, Student Worker (2020 - 2023)PhD student at BerkeleyDaniel LewinsohnIntern, Student Worker (2020 - 2023)
Daniel attends Colorado College and is majoring in Computer Science with a minor in Statistics. He first joined the Conrad Lab as a summer intern in 2020 and then was hired as student worker in February 2021. He works on the computational side of the lab on a variety of projects including investigating the role of splice variants in NOA, single-cell RNA-sequencing of Leydig Cells, and spatial transcriptomics of the testis.
Daniel's previous research experience includes public health study on HIV transmission and prevention at the Demond Tutu HIV Foundation in Cape Town, SA.
Outside of the lab, Daniel enjoys anything outside including biking, skiing, mountaineering, and soccer. He also enjoys learning about and participating in blockchain technology.
- Jacob RobinoRotation Student (January 2023)ONPRC
Jacob is a graduate student in the Program in Biomedical Sciences (PBMS). He joined the Conrad lab as a rotation student in January 2023, where he characterizes germline mutations in rhesus macaques to study the history of spermatogenic cell lines.
Jacob earned a BS in Biology and a BA in Psychology at the University of Portland (UP) in 2018, and believes that his psychology background helps him understand biology. During his studies at UP, Jacob helped isolate antimicrobial compounds from the Oregon grape with Dr. Angela Hoffman.
After finishing his undergraduate education, Jacob worked as a research assistant at the Oregon National Primate Research Center (ONPRC) for four years. Under the direction of Dr. Oleg Varlamov, Jacob helped research the effects of a high-calorie diet on both the hematopoietic system and adipose tissue. Jacob developed novel methods of characterizing the morphology of white adipose tissue.
Outside of the lab, Jacob likes to read about psychology and anthropology, play computer games with his cousins, or play board games with his friends.
- Alex StendahlResearch Assistant (2019 - 2022)Med student at OHSU
Alex joined the Conrad lab as a senior research assistant in November 2019, where she is spearheading the technical aspects of several sequencing projects, including validating variants found in the GEMINI population. Coming to the lab with an ecology background, Alex is excited to learn more about molecular biology and human genetics.
She received her BA in Environmental Studies from Dartmouth College where her research focused on arctic ecology. She completed a senior thesis analyzing the biology and biodiversity of insects and spiders in Greenland in the laboratory of Dr. Ross Virginia.
Outside of work, Alex enjoys cooking, going to the gym, playing board games, and spending time with family.
- Ieva GolubickaiteVisiting Scholar (July 2021 - June 2022)Lithuanian University of Health SciencesIeva GolubickaiteVisiting Scholar (July 2021 - June 2022)
Ieva is a Ph.D. student at the Lithuanian University of Health Sciences where her thesis research focuses on genetic alterations related to mitochondria in different types of cancer. She joined the Conrad Lab in August 2021 as a recipient of the Baltic-American Freedom Foundation (BAFF) scholarship for an 11-month professional internship in the US.
In 2020, Ieva was a visiting researcher in the Almstrup lab in Copenhagen University Hospital (Rigshospitalet), Denmark, where she learned sequencing of small RNA and native DNA using the CRISPR/Cas-9 mediated Nanopore approach. There, she also gained valuable knowledge in the field of reproduction and male infertility.
In the Conrad Lab Ieva hopes to augment her molecular biology expertise by gaining knowledge in computational biology, specifically in sequencing data analysis and interpretation.
Outside of the lab, Ieva enjoys traveling and exploring nature, hiking, reading books and spending time with her family and friends. She is also an animal and plant person!
- Rytis StakaitisVisiting Scholar (July 2021 - June 2022)Lithuanian University of Health SciencesRytis StakaitisVisiting Scholar (July 2021 - June 2022)
Rytis is a graduate student of Biology science at the Lithuanian University of Health Sciences, Neuroscience Institute, Laboratory of Molecular Neurooncology. He joined the Conrad Lab in August 2021 as a recipient of the Baltic-American Freedom Foundation (BAFF) scholarship for an 11-month professional internship in the US.
Rytis' PhD thesis is focused on the expression of microRNAs in glioblastoma and their prognostic value estimating the patient outcome. In addition, he is working on identifying m6A modifications in glioma in order to better understand the complex heterogeneity of astrocytic brain tumors. His goal in the Conrad Lab is to strengthen his knowledge in RNA-seq analysis and expand his scientific view of male infertility and its genetic causes.
Rytis gained expertise on mRNA/microRNA expression and CpG methylation at the Lithuanian University of Health Sciences, Kaunas, Lithuania. In 2019 he evolved an interest in the male reproductive system and its molecular biology during a 9-month traineeship in the Almstrup Lab in Copenhagen, Denmark, were he had the chance to join the PNLDC1 study, investigate small RNAs in testicular cancer and gain experience in small RNA and Nanopore sequencing experiments.
Outside of the lab Rytis is an active person who enjoys a variety of sports and outdoor activities: playing basketball, soccer, table tennis; enjoying the view while mountain skiing, hiking; or just throwing a football with friends in the backyard.
- Dharani ThirumalaisamyIntern (Fall 2021-Spring 2022)Remote
Dharani is a DMIC student at OHSU in the MS program in Bioinformatics and Computational Biology. She joined the Conrad Lab in September of 2021 where she works on detecting aneuploidies from DNA sequencing data in macaques.
Dharani received her B.Tech from Tamil Nadu in India. For her thesis she developed an immersive video game which was controlled by the flexion/relaxation of the bicep muscle. A logistic regression classifier was used to classify these signals from the muscles. After her undergraduate degree, she worked at Nine Point Medical in Bedford, MA as a Machine Learning Intern and at Malum Terminus Technologies Inc. In Coralville, IA a s a Computer Vision Engineer.
Outside of work Dharani loves to play badminton, go on hikes, cook, read books.
- Liina Nagirnaja, PhDPost-Doctoral Fellow (2015-2022)Barcelona, SpainLiina Nagirnaja, PhDPost-Doctoral Fellow (2015-2022)
Liina joined the Conrad lab as a post-doctoral fellow in January 2015 and has had a long-standing passion for the field of disease genetics.
In a transition away from her wet lab roots, Liina's research in the Conrad lab focuses on computational biology and male infertility. The genetic factors that cause spermatogenetic failure have remained poorly described and rare genetic aberrations are now the new suspects. In order to unveil this elusive spectrum of genetic variation, an ambitious multi-center project, called GEMINI, was initiated. This project aims to exome sequence thousand(s) of infertile men and Liina serves as its primary study coordinator.
Liina received her PhD from the University of Tartu, Estonia under the mentorship of Dr. Maris Laan and worked with Dr.Ilpo Huhtaniemi at Imperial College, London, UK. During these positions she investigated the various aspects of genetic predisposition to recurrent miscarriages.
Besides research, she enjoys hiking, sports and trips to different corners of the world.
- Benson ChongIntern (Fall 2021)OHSUBenson ChongIntern (Fall 2021)
Benson is a DMICE student at OHSU in the MS program in Bioinformatics and Computational Biology. He joined the Conrad Lab in September of 2021 where he works on creating predictive models to classify stages in spermatogenesis using scRNA-Seq expression data.
Benson received his BS in Biochemistry and Molecular Biology at Penn State. He then joined Dr. Wayne Curtis' lab in the Chemical Engineering Department to work on a selective gene therapy system for mature plants.
Outside of school/work, Benson likes biking, climbing, and producing music.
- Nicole RockweilerGraduate Student (2016-2021)Postdoc at Steve McCarrol Lab (Broad Institute)Nicole RockweilerGraduate Student (2016-2021)
Nicole joined the Conrad lab as a graduate student in August 2016 in the Computational and Systems Biology program at Washington University in St. Louis (WashU). Nicole’s thesis is on generating and analyzing spatial-temporal maps of postzygotic mutations in mammals.
Nicole received her B.S. from WashU, majoring in biomedical engineering and mathematics. After undergrad, Nicole worked for three years as a bioinformatician at the Genome Technology Access Center, a NGS sequencing core at WashU.
In her free time, Nicole enjoys fostering kittens and running half marathons. Nicole’s life goal is to become a genetics professor at a primarily undergraduate institution.
- Brian MillerComputational Biologist (2019-2021)Masters student at University of DenverBrian MillerComputational Biologist (2019-2021)
Brian joined the Conrad lab as a research assistant in June 2019. Brian's work in the Conrad Lab focuses on the GTEx project.
Brian received his B.S. in Cellular and Molecular Biology from Western Washington University in Bellingham, WA. His undergraduate research focused on analyzing RNA-Seq data to study the function and biological impact of noncoding sRNAs in the research laboratories of Drs. Suzanne Lee and Dan Pollard.
Outside of work Brian enjoys going to the gym, cooking, hiking, and playing ultimate frisbee with friends.
- Konstantin QueitschRotation Student (February 2021)OHSUKonstantin QueitschRotation Student (February 2021)
- Triona MathesonRotation Student (March 2020)OHSUTriona MathesonRotation Student (March 2020)
Triona is a graduate student in the Program in Molecular and Cellular Biosciences (PMCB). She joined the Conrad lab as a rotation student in March 2020, where she works to understand the underlying mechanisms of male (in)fertility from a variety of perspectives.
Triona received her BS in Biochemistry from the University of Portland in 2018. While there, she worked on several research projects including Modeling the Spread of the Zika Virus during the 2016 Olympics with Dr. Hannah Highlander and Isolating a Natural Insecticide from Yew Trees with Dr. Angela Hoffman. She is passionate about interdisciplinary research and is excited to learn more about the exciting fields of genomics and male infertility.
When she is not in the lab, Triona can be found on one of Oregon’s many hiking trails, playing tabletop games with her friends, or spending time with her cat.
- Kevin MacPhersonRotation Student (February 2020)OHSUKevin MacPhersonRotation Student (February 2020)
Kevin is a graduate student in the Program in Molecular and Cellular Biosciences (PMCB). He joined the Conrad Lab as a rotation student in February 2020, where he is learning how to detect aneuploidies from single-cell data and fine-map somatic mutations from bulk RNA-seq.
Kevin received his BS in Cell and Molecular Biology and Philosophy from Tulane University in 2014, followed by his MS in cell biology from Tulane the following year. In 2015, Kevin joined J. Michael Cherry's lab at Stanford University, where he served as a biocuration scientist for the Saccharomyces Genome Database (SGD) project until 2019. Learning about genome annotation and bioinformatics at SGD fostered Kevin's present-day research interests in single-cell technology, "omics", and precision medicine. Today, as a rotation student in the Conrad lab, Kevin is eager to gain experience in computational biology and genomics.
Outside of the lab, Kevin enjoys listening to music, going to the gym, motorcycling, martial arts, and spending time with friends in PMCB.
- Wu-Lin Charng, PhDPost-Doctoral Fellow (2016-2019)Postdoc at WUSTLWu-Lin Charng, PhDPost-Doctoral Fellow (2016-2019)
Wu-Lin joined the Conrad lab as a post-doctoral fellow in August 2016.
Her projects in the Conrad Lab focus on developing bioinformatic tools: (1) Integration of the functional information of proteins from the STRING database to a previously established PSAP (population sampling probability), which are p-values that evaluate the likelihood that the genotype observed in a single patient is causative. (2) Renewal of the original simulated PSAP values with an analysis-based model with several different variant functional annotation systems and population databases.
Wu-Lin received her PhD at Baylor College of Medicine in Developmental Biology and then worked as a postdoctoral associate in Dr. James R. Lupski's lab in the Department of Molecular and Human Genetics at Baylor College of Medicine. There, she focused on Mendelian genomics related projects to explore novel disease genes via whole exome sequencing (WES) and performed multiple functional assays to test the pathogenicity of variants identified from WES analyses.
- Min JungGraduate Student (2015-2019)Postdoc at GenentechMin JungGraduate Student (2015-2019)
Min joined the Conrad lab as a graduate student in April 2015. Her project focuses on the application of single-cell RNA-sequencing technologies to dissect gonadal defects in male infertility models.
Min received her B.S. in Clinical Laboratory Sciences at Stony Brook University. Her undergraduate research focused on developing a novel method to synchronize yeast meiotic cells to study chromosomal behaviors and recombination events in Dr. Nancy Hollingsworth’ s lab.
Outside of lab, Min enjoys running and baking, especially macarons. Her recent obsession has been playing with kittens that her roommate recently adopted and also policing them to keep them out of trouble!
- Eloise FadialIntern (Summer 2019)University of WyomingEloise FadialIntern (Summer 2019)
Eloise is working as an intern in the Conrad lab for the summer of 2019.
Eloise is currently a student at the University of Wyoming where she studies Chemical Engineering with a focus in Biomedical Engineering. She is also pursuing minors in Honors and Anthropology. At UW, she also works with various microfluidic devices in Dr. John Oakey’s lab.
Outside the lab, Eloise loves the outdoors. She enjoys hiking, backpacking, paddle boarding, skiing, etc. She also loves to travel and has been to 14 different countries. She has spent time living in France and in Italy.
- Abul Usmani, PhDPost-Doctoral Fellow (2014-2018)Postdoc at WUSTLAbul Usmani, PhDPost-Doctoral Fellow (2014-2018)
- Chengran YangGraduate Student (2016-2018)Graduate Student at Joe Dougherty lab (WUSTL)Chengran YangGraduate Student (2016-2018)
Chengran is a graduate student jointly supported with Jo Dougherty.
- Brian Leon-RicardoGraduate Student (2016-2018)Graduate Student at Chris Gurnett lab (WUSTL)Brian Leon-RicardoGraduate Student (2016-2018)
- Avinash RamuProgrammer (2011-2013), Graduate Student (2017-2018)Graduate Student at Barak Cohen lab (WUSTL)Avinash RamuProgrammer (2011-2013), Graduate Student (2017-2018)
- Casey DrubinMD Student (2016-2018)Casey DrubinMD Student (2016-2018)
- Jannette Rusch, PhDStaff Scientist (2014-2018)Staff Scientist at WUSTLJannette Rusch, PhDStaff Scientist (2014-2018)
- Amy Wilfert, PhDGraduate Student (2012-2017)Postdoc at Evan Eichler lab (UW)Amy Wilfert, PhDGraduate Student (2012-2017)
- Arthur Lee, MD, PhDGraduate Student (2011 -2016)Postdoc at Elizabeth Engle lab (Harvard)Arthur Lee, MD, PhDGraduate Student (2011 -2016)
- Nicholas Ho Rui Yuan, PhDGraduate Student (2011-2016)Postdoc at the Institute of Molecular and Cell Biology (A*STAR), SingaporeNicholas Ho Rui Yuan, PhDGraduate Student (2011-2016)
- Ni Huang, PhDPost-Doctoral Fellow (2012-2015)Research Associate at Gurdon InstituteNi Huang, PhDPost-Doctoral Fellow (2012-2015)
- Brianne TabersTechnician (2013-2016)Technician (WUSTL)Brianne TabersTechnician (2013-2016)
- Michiel Noordam, PhDPost-Doctoral Fellow (2011-2014)Junior PI at Maastricht UniversityMichiel Noordam, PhDPost-Doctoral Fellow (2011-2014)
- Ruth Miller, PhDPost-Doctoral Fellow (2011-2012)Ruth Miller, PhDPost-Doctoral Fellow (2011-2012)
- Lian-Bo WangRotation Student (Winter 2016/2017)Graduate Student at Li Ding lab (WUSTL)Lian-Bo WangRotation Student (Winter 2016/2017)
- Jessica FormanRotation Student (Fall 2016)Graduate Student at Jeff Gordon lab (WUSTL)Jessica FormanRotation Student (Fall 2016)
- Suhaira AhmadYSP Intern (Summer 2016)High school student at Collegiate School of Medicine and BioscienceSuhaira AhmadYSP Intern (Summer 2016)
- Jiayue LiuRotation Student (Spring 2016)Graduate Student at Rob Mitra lab (WUSTL)Jiayue LiuRotation Student (Spring 2016)
- Kristen WendtRotation Student (Fall 2014)Graduate Student at Himadri Pakrasi lab (WUSTL)Kristen WendtRotation Student (Fall 2014)
- Matthew BaileyRotation Student (Winter 2013/2014)Graduate Student at Li Ding lab (WUSTL)Matthew BaileyRotation Student (Winter 2013/2014)
- Nathan KoppRotation Student (Summer 2013)Graduate Student at Joseph Dougherty lab (WUSTL)Nathan KoppRotation Student (Summer 2013)
- Amy LangdonRotation Student (Summer 2013)Graduate Student at Gautam Dantas lab (WUSTL)Amy LangdonRotation Student (Summer 2013)
- Nishtha SinghalUndergraduate Research Scholar (Summer 2013)Co-founder at Zyme TechnologiesNishtha SinghalUndergraduate Research Scholar (Summer 2013)
- Chris NodaIntern (Summer 2012)Research Technician at WUSTLChris NodaIntern (Summer 2012)
- Francine CamachoUndergraduate Research Scholar (Summer 2012)Graduate Student at Princeton UniversityFrancine CamachoUndergraduate Research Scholar (Summer 2012)
- Henry SchreiberRotation Student (Spring 2012)Graduate Student at Scott Hultgren lab (WUSTL)Henry SchreiberRotation Student (Spring 2012)
- Zane GoodwinRotation Student (Spring 2012)Graduate Student at Cristina Strong's lab (WUSTL)Zane GoodwinRotation Student (Spring 2012)
- Breanne HartyRotation Student (Fall 2011)Graduate student at Kelly Monk's lab (WUSTL)Breanne HartyRotation Student (Fall 2011)
- Ruteja BarveRotation Student (Summer 2011)Graduate student at Charles Gu's lab (WUSTL)Ruteja BarveRotation Student (Summer 2011)
- Shelina RamnarineRotation Student (Summer 2011)Graduate student at Nancy Saccone's Lab (WUSTL)Shelina RamnarineRotation Student (Summer 2011)